AICAR Research Peptide

AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a synthetic adenosine analog widely studied for its role in cellular energy regulation and metabolic signaling. It functions as an AMP mimetic, allowing it to influence intracellular pathways associated with energy balance and mitochondrial activity. Within biochemical research, AICAR has gained significant attention due to its ability to activate key regulators of metabolic homeostasis, particularly under conditions of energy stress.

Its role as a metabolic modulator makes it highly relevant in studies focused on glucose metabolism, lipid oxidation, and cellular energy dynamics, especially in contexts involving endurance physiology and mitochondrial efficiency.

Mechanism of Action

AICAR exerts its primary effects through activation of the AMP-Activated Protein Kinase (AMPK), a central regulator of cellular energy homeostasis. Once inside the cell, AICAR is phosphorylated to form ZMP (AICAR monophosphate), which mimics AMP and activates AMPK signaling pathways.

Activation of AMPK leads to a cascade of downstream effects, including increased glucose uptake, enhanced fatty acid oxidation, and inhibition of anabolic processes such as lipid and protein synthesis. This shift promotes energy conservation and improved metabolic efficiency, particularly under conditions of low cellular energy availability.

Additionally, AMPK activation influences mitochondrial biogenesis through pathways involving PGC-1α, supporting research into cellular adaptation, endurance mechanisms, and metabolic flexibility.

Pharmacological Characteristics

AICAR is characterized by its ability to modulate metabolic pathways without directly interacting with classical hormone receptors. Its effects are closely tied to intracellular energy status, making it a valuable compound for studying metabolic stress responses and energy utilization.

It is associated with increased insulin sensitivity, enhanced lipid metabolism, and improved mitochondrial function. Research applications frequently explore its role in endurance-related pathways, skeletal muscle adaptation, and systemic metabolic regulation.

Due to its mechanism, AICAR is often studied in models involving metabolic disorders, energy imbalance, and cellular stress adaptation.

Product Specifications

Compound: AICAR

Form: Lyophilized Powder

Purity: High-Purity Peptide Synthesis

Storage: Recommended storage at 2–8°C

Stability: Maintains structural integrity under controlled conditions

Application: Research Use Only

Advanced Peptide Technology

AICAR is produced using advanced synthesis and purification techniques to ensure high molecular purity and consistency. Each batch undergoes rigorous analytical validation, including high-performance liquid chromatography (HPLC) and mass spectrometry (MS), confirming identity and structural integrity.

Strict quality control protocols are implemented to support reproducibility and reliability across laboratory research applications, meeting high-standard scientific requirements.

Disclaimer

This product is intended strictly for research purposes only and is not approved for human consumption, medical use, or therapeutic application.